Pacadon-T Tablets

COMPOSITION:
Each effervescent tablet contains:
Paracetamol BP 325 mg
Tramadol Hydrochloride BP 37.5 mg
Excipients q.s.

INDICATIONS:
Pacadon-T Fizz is indicated to provide fast, effective relief from acute and severe pain like post surgical pain, rheumatic pain, headache including migraine, backache, sciatica, neuralgia, muscular & joint pain including sport injuries, toothache and pain associated with dental procedures.

DESCRIPTION:
Pacadon-T Fizz is a combination of Paracetamol and Tramadol hydrochloride which offer potential therapeutic benefits in relation to the onset of analgesic effects. Paracetamol blocks the effect of endogenous pyrogen on the hypothalamic heat-regulating center by inhibiting prostaglandin synthesis. Paracetamol is rapidly and completely absorbed with peak plasma concentration occurring in 10 to 60 minutes after oral administration and the half-life in plasma is about 2 hours after therapeutic doses. Paracetamol is uniformly distributed throughout most body fluids. Paracetamol undergoes CYP-mediated N-hydroxylation to form N-acetyl-p-benzoquinoneimine (NAPQI), a highly reactive metabolite. This metabolite normally reacts with sulfhydryl group of glutathione and is rendered harmless. Elimination is essentially through the urine. 90% of the ingested dose is eliminated via kidneys within 24 hours, principally as glucuronide (60 to 80%) and sulphate conjugates (20 to 30%). Less than 5% is eliminated in unchanged form. Elimination half life is about 2 hours. Tramadol hydrochloride is an opioid analgesic that acts on the central nervous system. It inhibits neuronal uptake of noradrenaline and enhance the secretion of serotonin. Tramadol hydrochloride is almost completely absorbed and the absolute bioavailability is approximately 75%. Tramadol hydrochloride is rapidly distributed in the body with a volume of distribution of 2-3 L/kg. The plasma elimination half-life of Tramadol hydrochloride is 6.5 hours.

CONTRAINDICATIONS:
Pacadon-T Fizz is contraindicated in any situation where opioid are contraindicated, including acute intoxication with any of the following: alcohol, hypnotics, narcotics, centrally acting analgesics or psychotropic drugs. It should not be administered to patients with known hypersensitivity to Tramadol, Paracetamol and other component of this product.

SIDE EFFECTS:
Constipation, hepatotoxicity, somnolence, nausea and vomiting may occur. Symptoms of side effects, if any, should subside after discontinuing the medicine. If symptoms persist, please consult the physician.

DOSAGE:
Adults and children above 12 years: An initial dose of 2 effervescent tablets is recommended. Additional doses can be taken as needed, not exceeding 8 effervescent tablets in a day. The dosing interval should not be less than 6 hours.
Directions for use:- Allow to dissolve the tablet completely in half a glass of water and drink immediately. Do not chew or swallow the tablet.

STORAGE CONDITIONS:
Store in a cool, dark & dry place. Keep out of reach of children.

PRESENTATION:
4 tablets packed in a strip and such 4 strip packed in a carton with insert.