Pacadon-T Tablets

COMPOSITION:
Each effervescent tablet contains:
Paracetamol BP 325 mg
Tramadol Hydrochloride BP 37.5 mg
Excipients q.s.

INDICATIONS:
Pacadon-T Fizz is indicated to provide fast, effective relief from acute and severe pain like post surgical pain, rheumatic pain, headache including migraine, backache, sciatica, neuralgia, muscular & joint pain including sport injuries, toothache and pain associated with dental procedures.

DESCRIPTION:
Pacadon-T Fizz is a combination of Paracetamol and Tramadol hydrochloride which offer potential therapeutic benefits in relation to the onset of analgesic effects. Paracetamol blocks the effect of endogenous pyrogen on the hypothalamic heat-regulating center by inhibiting prostaglandin synthesis. Paracetamol is rapidly and completely absorbed with peak plasma concentration occurring in 10 to 60 minutes after oral administration and the half-life in plasma is about 2 hours after therapeutic doses. Paracetamol is uniformly distributed throughout most body fluids. Paracetamol undergoes CYP-mediated N-hydroxylation to form N-acetyl-p-benzoquinoneimine (NAPQI), a highly reactive metabolite. This metabolite normally reacts with sulfhydryl group of glutathione and is rendered harmless. Elimination is essentially through the urine. 90% of the ingested dose is eliminated via kidneys within 24 hours, principally as glucuronide (60 to 80%) and sulphate conjugates (20 to 30%). Less than 5% is eliminated in unchanged form. Elimination half life is about 2 hours. Tramadol hydrochloride is an opioid analgesic that acts on the central nervous system. It inhibits neuronal uptake of noradrenaline and enhance the secretion of serotonin. Tramadol hydrochloride is almost completely absorbed and the absolute bioavailability is approximately 75%. Tramadol hydrochloride is rapidly distributed in the body with a volume of distribution of 2-3 L/kg. The plasma elimination half-life of Tramadol hydrochloride is 6.5 hours.

CONTRAINDICATIONS:
Pacadon-T Fizz is contraindicated in any situation where opioid are contraindicated, including acute intoxication with any of the following: alcohol, hypnotics, narcotics, centrally acting analgesics or psychotropic drugs. It should not be administered to patients with known hypersensitivity to Tramadol, Paracetamol and other component of this product.

SIDE EFFECTS:
Constipation, hepatotoxicity, somnolence, nausea and vomiting may occur. Symptoms of side effects, if any, should subside after discontinuing the medicine. If symptoms persist, please consult the physician.

DOSAGE:
Adults and children above 12 years: An initial dose of 2 effervescent tablets is recommended. Additional doses can be taken as needed, not exceeding 8 effervescent tablets in a day. The dosing interval should not be less than 6 hours.
Directions for use:- Allow to dissolve the tablet completely in half a glass of water and drink immediately. Do not chew or swallow the tablet.

STORAGE CONDITIONS:
Store in a cool, dark & dry place. Keep out of reach of children.

PRESENTATION:
4 tablets packed in a strip and such 4 strip packed in a carton with insert.

Cinepar-75 Injection

Cinepar 75 (2)a

COMPOSITION:
Each 3 ml contains:
Diclofenac Sodium BP 75 mg
Benzyl Alcohol BP 4% v/v
Water for Injection BP q.s.

INDICATIONS:
Cinepar-75 is indicated for the treatment of:
Intramuscular injection

  • Post traumatic and post operative pain, inflammation and swelling
  • Exacerbations of inflammatory and degenerative forms of rheumatism: rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, spondyloarthritis, non-articular rheumatism
  • Acute attacks of gout
  • Painful conditions due to inflammation of non rheumatic origin
  • Pain caused by kidney stone, injuries & fractures
  • Painful syndromes of the vertebral column
  • Renal colic and biliary colic
  • Severe migraine attacks.

DESCRIPTION:
Pharmacodynamics
Cinepar-75 contains Diclofenac sodium which is a Non steroidal anti-inflammatory drug. It inhibits cyclo-oxygenase, a splice variant of COX-1 and COX-2 and limits the production of prostaglandins.
Pharmacokinetics
Cinepar-75 administered by intramuscular route achieves a mean peak plasma concentration of 2.5µg/ml in 20 minutes. 99.7% of diclofenac is bound to serum proteins, mainly to albumin (99.4%). The apparent volume of distribution is 0.12 to 0.17 L/kg. The terminal half-life in plasma is 1 to 2 hours. About 60% of the administered dose is excreted in the urine as the glucuronide conjugate and the rest of the dose is eliminated as metabolites through the bile in the faeces.

CONTRAINDICATIONS:
Cinepar-75 is contraindicated in conditions of severe hepatic, renal or cardiac failure, active gastric or intestinal ulcer, bleeding or perforation and in patients with known hypersensitivity to Diclofenac sodium. Concomitant NSAID or anticoagulant use including low-dose Heparin with Diclofenac sodium should be avoided. It is also contraindicated in last trimester of pregnancy.

SIDE EFFECTS:
Blood and lymphatic system disorder: Vary rare: Thrombocytopenia, leukopenia and anaemia
Immune system disorder: Rare: Hypersensitivity, anaphylactic and analhylactoid reactions
Nervous system disorder: Common: Headache, dizziness; Rare: Somnolence; Very rare: Paraesthesia, memory impairment and convulsion
Eye disorder: Very rare: Visual disturbance, blurred vision and diplopia
Cardiac disorders: Very rare: Palpitation, chest pain and myocardial infraction

DOSAGE:
Adults
Intramuscular Injection
The dose is generally one 75 mg ampoule daily, given by deep intragluteal injection into the upper outer quadrant. In severe cases (e.g. colic), the daily dose can exceptionally be increased to two injections of 75 mg, separated by an interval of a few hours (one into each buttock). Alternatively, one ampoule of 75 mg can be combined with other pharmaceutical forms of Diclofenac sodium (e.g. tablets, suppositories) up to a total maximum daily dose of 150 mg. In migraine attacks, clinical experience is limited to initial use of one ampoule of 75 mg administered as soon as possible, followed by suppositories up to 100 mg on the same day if required. The total dose should not exceed 175 mg on the first day.
Intravenous Infusion
Diclofenac sodium solution for injection must not be given as an intravenous bolus injection. Immediately before starting an intravenous infusion, Diclofenac sodium solution for injection must be diluted with saline 0.9% or glucose 5% infusion solution buffered with sodium bicarbonate according to the instructions given in section method of administration. Two alternative dosage regimens of Diclofenac sodium solution for injection are recommended. For the treatment of moderate to severe post-operative pain, 75 mg should be infused continuously over a period of 30 minutes to 2 hours. If necessary, treatment may be repeated after a few hours, but the dose should not exceed 150 mg within any period of 24 hours.
For the prevention of post-operative pain, a loading dose of 25 mg to 50 mg should be infused after surgery over 15 minutes to 1 hour, followed by a continuous infusion of about 5 mg per hour up to a maximum daily dose of 150 mg.

STORAGE CONDITIONS:
Store in a cool, dark & dry place. Keep out of reach of children.

PRESENTATION:
3 ml solution filled in a glass ampoule and such 5 ampoules packed in a carton with insert.
3 ml solution filled in a glass ampoule and such 10 ampoules packed in a carton with insert.

Cinepar Treo Tablets

Cinepar Treo

COMPOSITION:
Each uncoated tablet contains:
Diclofenac Sodium BP 50 mg
Paracetamo lBP 500 mg
Chlorzoxazone USP 500 mg

Colour : Red oxide of Iron

INDICATIONS:
Cinepar Treo is indicated during pain and inflammation due to muscle spasms and the associated musculoskeletal conditions like :

  • Myalgia, myositis, sprains, strains, traumatic injury of the muscles, soft tissue rheumatism like bursitis and fibromyalgia.
  • Diseases of the joints (Arthritis e.g. osteoarthritis & rheumatoid arthritis; attacks of gout and spondylitis).
  • Low back pain, acute prolapsed disc and pain syndrome after removing the disc.
  • Post operative pain and inflammation, sports injuries, torticollis, primary amenorrhea, proctitis and
    adnexitis.
  • Neurological disorders (multiple sclerosis, spinal cord diseases, radicular syndrome and cerebral palsy).

DESCRIPTION :
Red spotted white elongated, scored on one side.

CONTRAINDICATIONS :
Cinepar Treo is contraindicated in conditions of liver disease, asthma, hypotension, renal failure and in patients with known hypersensitivity to Paracetamol, Diclofenac Sodium and Chlorzoxazone.

SIDE EFFECTS :
Gastrointestinal disturbances, epigastric pain, dizziness, hemolysis, hepatotoxicity, peptic ulcer, nausea and vomiting may occur. Symptoms of side effects, if any, should subside after discontinuing the medicine. If symptoms persist, please consult the physician.

DOSAGE :
For Adults & Children above 12 years : One Tablet 3-4 times a day or as directed by physician.

STORAGE CONDITIONS :
Store in a cool, dark & dry place. Keep out of reach of children.

PRESENTATION :
10 Tablets are packed in a blister and such 10 blisters packed in a carton with insert.

Cinepar Kid Lite Suspension

Cinepar kid lite

COMPOSITION:
Each 5 ml of suspension contains :
Paracetamol BP 162.5 mg
Ibuprofen BP 100 mg
In a flavoured sugar free base

INDICATIONS:
Fever, cold & flu, relief of mild to moderate pain such as toothache, teething pain, pain of growing bones, ear pain in inflammation of middle ear, musculoskeletal pain of all types including sport injuries, wound aches, post operative pain, general aches & pain, infective inflammation & post-immunization fever.

DESCRIPTION:
In Cinepar Kid Lite Suspension, Paracetamol inhibits cyclooxygenase mainly in CNS. Antipyretic effect of Paracetamol is attributed to inhibition of biosynthesis of prostaglandin directly in hypothalamus, in particular, prostaglandins E2 and F2, which are mediators of thermoregulation center. Ibuprofen has prominent anti-inflammatory effects in addition to analgesic and antipyretic actions. Ibuprofen is a potent inhibitor of the enzyme cyclooxygenase which results to reduction of synthesis of prostaglandins which take part in pathogenesis of pain and inflammation.
In Cinepar Kid Lite Suspension, Paracetamol is readily absorbed from the gastro-intestinal tract with peak plasma concentrations occurring about 10-60 minutes after oral administration. Paracetamol is distributed into most body fluids. Paracetamol is metabolized in the liver and excreted in the urine. The elimination half-life of Paracetamol varies from about 1 to 3 hours. In Cinepar Kid Lite Suspension, Ibuprofen is readily absorbed from the gastro-intestinal tract and peak plasma concentrations occur in about 1 to 2 hours after administration. Ibuprofen is extensively bound to plasma proteins. It is rapidly excreted in the urine mainly as metabolites and their conjugates.

CONTRAINDICATIONS:
Known hypersensitivity to any of the ingredients, bronchospasm, asthma, peptic ulcer, recent gastrointestinal bleeding, renal failure and hypertension.

SIDE EFFECTS:
Hypersensitivity, active Peptic ulcer or GI bleeding, Pancreatitis, Skin rashes, Nausea, Vomiting, Epigastric discomfort, Dizziness, different allergic reactions may occur occasionally. Symptoms of side effects (if any) should subside after discontinuing medicine. If symptoms persist, please consult doctor.

DOSAGE:
6-12 years: 10 to 15 ml, 3 times a day;
4-6 years: 5 to 10 ml, 3 times a day;
1-4 years: 5 ml, 3 times a day;
Children 6 months-1 year: 2.5 ml to 5 ml, 3 times a day or as directed by the physician.

STORAGE:
Store in a cool, dark & dry place. Keep out of reach of children.

PRESENTATION:
60 ml suspension filled in amber coloured PET bottle, one bottle packed in a carton with insert.

Cinepar Kid Suspension

cinepar kid

COMPOSITION:
Each 5 ml of suspension contains :
Ibuprofen BP 100 mg
Paracetamol BP 162.5 mg

INDICATIONS:
Cinepar Kid Suspension is indicated for fever, relief of mild to moderate pain such as teething pain, pains of growing bones, musculo skeletal pain of all types including sports injuries, wound aches, infective inflammation, post-operative pain, general aches and pains.

DESCRIPTION:
Cinepar Kid suspension is a combination of Paracetamol & Ibuprofen. It is a long-established non-prescription antipyretic & analgesic drug for fever, pain and inflammation

CONTRA-INDICATIONS:
Known sensitivity to the components of the medicine, bronchospasm, asthma, peptic ulcer, recent gastrointestinal bleeding, renal failure, hypertension on treatment.

SIDE EFFECTS:
Hypersensitivity, active peptic ulcer or GI bleeding, pancreatitis, skin rashes, nausea, vomiting, epigastric discomfort, dizziness and other allergic reactions may occur occasionally. Symptoms of side effects (if any) should subside after discontinuing medicine. If symptoms persist, please consult doctor.

PRECAUTIONS:
Cinepar Kid should be given with care to patients with impaired kidney or liver function. Check the expiry on the pack and do not use after expiry date of medicine.

DOSAGE & ADMINISTRATION:
Children 7 to 12 years : 5 to 15 ml 3 times daily,
4 to 6 years : 5 to 10 ml 3 times daily,
1 to 3 years : 5 ml 3 times daily,
Infants, 6 month to 1 year : 2.5 ml to 5 ml 3 times daily or as directed by the physician.

STORAGE:
Store in a cool, dark & dry place. Keep out of reach of children.

PRESENTATION:
Cinepar Kid Suspension is available in 60 ml PET bottle.

Cinepar Tablets

Cinepar tab

COMPOSITION:
Each tablet contains:
Paracetamol 500 mg
Diclofenac Sodium 50 mg

INDICATIONS:

  • Rheumatoid arthritis
  • Osteoarthritis
  • Low back pain and other acute musculoskeletal disorders such as tendinitis, tenosynovitis, bursitis, sprains, strains and dislocations
  • Ankylosing spondylitis
  • Control of pain and inflammation in orthopaedic, dental and other minor surgery
  • Juvenile chronic arthritis
  • Postoperative pain
  • Headache
  • Body ache
  • Reduction of fever

PHARMACOLOGICAL ACTION:
Cinepar is an Analgesic Anti inflammatory combination. Diclofenac is a potent non-steroidal anti-inflammatory drug (NSAID). Paracetamol is a long-established non-prescription antipyretic analgesic drug. When used together the actions of paracetamol set in earlier and provides pain relief before the effects of diclofenac sodium set in.

PHARMACOKINETICS:
Paracetamol is readily absorbed from the gastro-intestinal tract with peak plasma concentrations. Paracetamol is distributed into most body tissues. It crosses the placenta and is present in breast milk. Less than 5% is excreted as unchanged Paracetamol. The elimination half-life varies from about 1 to 3 hours.Diclofenac is well absorbed following oral dosing but, with administration of preparation, the time to peak plasma concentration can be variable. There is some presystemic elimination but about 60% of the oral dose reaches the systemic circulation.

CONTRA-INDICATIONS:
Known sensitivity to Paracetamol, active or suspected peptic ulcer or gastro-intestinal bleeding. Previous sensitivity to diclofenac sodium, asthmatic patients in whom attacks of asthma, urticaria or acute rhinitis are precipitated by aspirin or other NSAID’s possessing prostaglandin synthetase inhibiting activity. Paracetamol should be given with care to patients with impaired kidney or liver function.

SIDE EFFECTS:
Hypersensitivity, active peptic ulcer or GI bleeding, Pancreatitis, skin rashes and other allergic reactions may occur occasionally. Symptoms of side effects (if any) should subside after discontinuing of medicine. If symptoms persist, please consult doctor.

PRECAUTIONS:
Check the expiry on the pack and do not use after expiry date of medicine.

DOSAGE & ADMINISTRATION:
For Adults & Children older than 12 yrs :One Tablet 2-3 times a day after meals or as directed by the physician.

PRESENTATION:
Cinepar tablets are available in blister of 10 tablets.